MyBioSource.com's ABCG2 Mouse mAb is a Mouse monoclonal antibody. It reacts with Human, Mouse, and Non-Human Primate. This antibody has been shown to work in applications such as: ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, and Western Blot.
Description
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon